All courses will be held in parallel at the Montreal Airport Marriott In-Terminal Hotel.

Laser Ablation Inductively Coupled Plasma Mass Spectrometry. Instructor: Henry Longerich (Earth Sciences, Memorial University of Newfoundland, St. John’s, NL A1B 3X5, Canada, henryl@mun.ca)

While the emphasis of this course deals with the fundamentals of laser ablation (LA) sample introduction into an inductively coupled plasma mass spectrometer (ICPMS), this course will start with a personal early history of ICPMS, which I first “discovered” in 1983. Shortly after, in the spring of 1984, the first ELAN 250 instrument was delivered by the Ontario company SCIEX to the National Research Council of Canada, an Ottawa, Ontario laboratory. Just before Christmas in 1984, we installed the tenth commercially delivered instrument from SCIEX. A few years later, in 1989, we built our first LA system for applications emphasizing the micro analysis of development of both the ICPMS and later the LA systems, and a recommendation to look for the major advance in elemental and isotopic analysis, which is long overdue.

A discussion will follow concerning the ICPMS, which is a fundamental component of a complete (LA-ICPMS) system, including most importantly the detectors, system settling times, and the operator choices of data acquisition parameters. Understanding of these components of the ICPMS are essential for data interpretation, the production of quality results, as well as assisting a buyer in choosing among available commercial instruments, noting that some special considerations should be made when purchasing an ICPMS for LA applications. Details of LA systems in general, with a special detailed discussion on choices of lasers, laser induced elemental fractionation, and analytical detection limits will be included.

Risk Assessments on Nanomaterials Instructor: Petra Krystek (Vrije University (VU) Amsterdam, Amsterdam, The Netherlands petra.krystek@vu.nl)

This course will provide an overview about the role of analytical techniques (especially inductively coupled plasma mass spectrometry (ICPMS) and complementary techniques) in the characterization of (engineered) nanomaterials, the analysis of (contact) matrices from human exposure scenarios to nanoproducts as well as in assessments regarding occupational exposure.

The stepwise procedures from sampling, sample pre-treatment and measurements by ICPMS will be discussed while aspects of validation and quality control will be involved too. In these cases, ICPMS is used for elemental identification and quantification. The possibilities by single particle (sp) ICPMS will be shown as well.

The knowledge on exposure and possible toxicity of nanotechnological products is growing but still limited, resulting in a great relevance of human risk assessments while external exposure can occur by inhalation, ingestion, injection and/or skin contact. In addition, internal exposure (e.g (bio)distribution) is of concern too. For answering all these questions, integrated approaches based on the use of ICPMS including hyphenation to e.g. asymmetric flow field flow fractionation (AF4) and other complementary techniques are needed. An overview about the selection criteria of matrices and analytical procedures by ICPMS will be given. Examples with e.g. body fluids, saliva, tissues (organs) and skin will be discussed more closely.

The course will be given as interactive training; on request, aspects like e.g. environmental assessments or exposure models can be touched too