FULL-DAY COURSES ON 11 AUGUST 2022

All courses will be held in parallel at the Four Points by Sheraton, Kingston, ON.

Designing or Modifying a Laboratory for Trace and Ultra-trace Analyse Instructor: Ela Bakowska, Elba Elemental Consulting, PO Box 1050, Corning, NY 14830ela@bakowska.com)

The demand to measure trace and ultra-trace levels of analytes is surging due to emerging applications that require the measurement or control of elemental levels at increasingly lower concentrations. Trace and ultra-trace analyses require the use of instrumentation capable of delivering the desired information; for example, replacing the previously used inductively coupled plasma (ICP) optical emission spectrometer with ICP mass spectrometry (MS) or upgrading an existing ICP-MS instrument to a more sensitive model. However, acquiring the suitable analytical instrumentation is just the beginning of the quest to produce meaningful analytical results. It is critical to evaluate all factors which can impact the quality of analytical results. Different aspects of handling the samples include: the sample itself (the sampling process, its storage, and preparation), laboratory, reagents, analysis, and finally the Analyst. The level of care in sample handling depends upon the concentration levels of the analytes to be determined during the analysis. Specific examples of appropriate reagents and lab supplies will be listed. Cost saving alternatives for lab design and operation will be presented. Sample preparations considerations for different applications (semiconductor, environmental, clinical) will be discussed. Sources of specific elemental contaminations and ways of eliminating or minimizing them will be listed. Guidelines for procurement of a new ICP-MS instrument will be shared with the participants. The course would benefit scientists and managers adapting their current laboratory (renovating or remodeling) or designing a new laboratory to optimize the performance of new or existing ICP-MS instrumentation. Ela Bakowska is Research Associate at Corning RDC and Technical Director at Elba Elemental Consulting and has more than 30 years of experience in ICP-MS.

Human Health and Ecological Risk Assessment Instructor: Iris Koch (Royal Military College of Canada, Kingston, ON, Canada Koch-i@rmc.ca)

The term “risk assessment” is often used as a general term for the applicability or end use of many analytical methodologies. In this short course, the basic concepts of human health and ecological risk assessment will be provided for non-practitioners. Topics such as guideline development, selection of contaminants of potential concern, identification of receptors and exposure pathways, toxicology, and estimation of non-cancerous and cancerous risk will be covered. Participants will carry out calculations in case studies and will learn about the complexities of selecting variables in circumstances where clear guidance is not available. Aspects of analytical testing, quality assurance and quality control, and less standard or developing methods will be discussed in the context of both human health and ecological risk assessment. The uncertainties and limitations in the process will be examined, as well as sensitivity analysis. The course will draw upon Canadian federal guidance for risk assessment as this is freely available and representative of guidance and protocols used in many other jurisdictions.

Single Particle Inductively Coupled Plasma Mass Spectrometry and its Variations Instructor: Diane Beauchemin (Department of Chemistry, Queen’s University, Kingston, ON K7L 3N6, Canada diane.beauchemin@queensu.ca )

This course will go over the principles of the conventional single particle inductively coupled plasma mass spectrometry (spICPMS) approach for the measurement of nanoparticles (NPs) suspended in solution. Its features and limitations will be discussed, along with the effect of settling time on accuracy and the steps involved in data processing to convert the count rate measured by spICPMS into a NP size. Variations of spICPMS will then be described, using flow injection (FI), where a discrete known volume of NPs suspension is injected into a continuous carrier flow, or monosegmented flow analysis (MSFA), where injection is done within an air bubble in a continuous carrier flow. Combining FI or MSFA to spICPMS simplifies the analysis by eliminating the need to measure the sample uptake rate, which is required with the conventional spICPMS method. With either FI-spICPMS or MSFA-spICPMS, the transport efficiency is not required for measurement of NP size, unlike with the conventional spICPMS approach, and is only required for measurement of NPs concentration.

Validation assessment and ISO/IEC 17025 - an interactive session Instructor: Rob Ritsema (RR Quality Consultancy, Amersfoort, the Netherlands; robritsema@gmail.com )and Petra Krystek (Vrije Universiteit (VU), Amsterdam, the Netherlands;petra.krystek@vu.nl )

This course will give an overview about the validation of analytical methods and procedures which is an integral part of any good analytical practice. Method validation is the process used to confirm that the analytical procedure employed for a specific test is suitable for its intended use. Results from method validation can be used to judge the quality, reliability and consistency of analytical results. For making this information as practice relevant as possible, several examples like a procedure for the determination of selected elements in water by ICPMS will be discussed in detail.

Special attention will be given to sampling and storage. Other examples from the inorganic analytical field of environmental, food and biological matrices will be covered too. Besides the methodological aspects and the obtained analytical results, the ten most relevant performance characteristics (limit of detection, recovery, repeatability, reproducibility, measuring range, trueness, lack of fit, expanded uncertainty of measurement, robustness and selectivity) are defined, calculated and discussed; also in relation if the analytical method should fulfil of the accreditation standard ISO/IEC 17025. Crucial aspects of the ISO/IEC 17025 (2017) will be discussed too. This course will be held as an interactive session. Rob Ritsema and Petra Krystek are freelance lead assessors at the Dutch Accreditation Council performing ISO/IEC 17025 technical assessments at accredited laboratories in mainly the Netherlands.

Control Charts for Analytical Chemists Instructor: Edgar F. Paski ed@edpaski.com )

Workshop objectives: To give participants an understanding of control charts and their application in testing laboratories.

What you will learn ? How to set up and use control charts for monitoring central tendency and precision. ? Why control charts are essential for laboratories accredited to ISO/IEC 17025:(2005 and 2017) ? How to use control charts for measurement uncertainty estimates ? Using control charts for monitoring trends ? Role of control charts in establishing metrological traceability of measurements

Who should attend: This one day workshop is designed for individuals engaged in making chemical, physical and microbiological measurements, regulatory body personnel, policy makers, users of measurement data. The topics covered are relevant to analytical chemists, microbiologists, laboratory personnel, process engineers, managers, quality assurance and quality control specialists as well as supervisory personnel.

Practicum: Please bring an empty USB flash drive and a notebook PC with spreadsheet software (LibreOffice Calc or Microsoft Excel).

Workshop content

Introduction: Why control charts are an essential part of a lab’s quality system

* Meeting requirements of the ISO/IEC 17025:(2005 and 2017) Standards
* Common types of control charts: central tendency, precision
* Trends: the basics of detection and evaluation of trends
* Tools for charting: pen & paper, spreadsheets, SPC software
* What to chart

Statistics: The basis for control charting

* Confidence intervals for the mean and standard deviation
* Inference and decisions
* Probabilities of events occurring and setting limits
* How many points are needed for establishing limits
* Updating and revising limits
* Certified reference materials (CRM’s) and their specifications
* Practicum

Central tendency: The Shewhart Chart

* Establishing zones and limits
* WECO, Nelson and Westgard rules for trends
* Bias and measurement uncertainty
* Practicum

Precision: Range and Range Ratio Charts

* When to use range charts and range ratio charts
* Calculating range and range ratios
* Factors for warning and control limits
* Use in estimating measurement uncertainty
* Trends
* Practicum

Specialty charts: Charts for trends

* Cusum for gradual drift
* J Chart for trends and conventional limits
* Practicum

Facilitator

Ed Paski earned his B.Sc. in Chemistry at the University of Waterloo and his Ph.D. in Analytical Chemistry at the University of British Columbia. He has worked in industry and government in the areas of mining and mineral exploration, environmental chemistry, pulp and paper technology. He teaches courses in analytical atomic spectrometry, quality assurance and the assayer certification program at the British Columbia Institute of Technology (BCIT). He assesses testing laboratories to the ISO/IEC 17025:(2005 and 2017) Standards for the Standards Council of Canada (SCC) and the Canadian Association for Laboratory Accreditation (CALA). His professional interests include: plasma spectrochemistry, sampling, chemometrics, automated chemical analysis, trace elements in geological and environmental materials, quality assurance, laser applications in analytical chemistry, multidimensional luminescence spectrometry, computer applications in analytical chemistry.